The effect of amino acids on ouabain-induced [45Ca]calcium ion uptake into slices of rat cerebral cortex [proceedings].

radioisotopic (Daly, 1972; McIlwain, 1974) studies. Thus the post-stimulation increase in synaptosomal cyclic AMP can most readily be seen as migration of the nucleotide, by intracellular or extracellular routes, from those localized sites, although there is also a possibility of adenosine as intermediate. Independently of route, the delayed increase in nerve-terminal cyclic AMP is significant in interpreting slow changes in potential and cell-firing which follow excitation in cerebral systems (McIlwain, 1976).